Barden G A
South Med J. 1980 Nov;73(11):1543-4. doi: 10.1097/00007611-198011000-00040.
With increased use of the potent anticancer drug doxorubicin HCl (Adriamycin), there are increasing numbers of reports of local severe tissue damage at the venous administration sites. I have described a 70-year-old woman in whom extravasation of this drug produced a characteristic indolent ulcer on the hand and wrist. Expectant nonoperative care was followed six weeks later by debridement and a split-thickness skin graft which failed to take. Repeat debridement with porcine grafts stimulated granulation tissue, so that split-thickness skin grafting could give an acceptable functional and cosmetic result.
随着强效抗癌药物盐酸多柔比星（阿霉素）使用的增加，静脉给药部位出现局部严重组织损伤的报告越来越多。我曾描述过一名70岁女性，该药物外渗在其手部和腕部形成了典型的无痛性溃疡。六周后采用保守非手术治疗，随后进行清创和中厚皮片移植，但移植未成功。重复清创并使用猪皮移植刺激肉芽组织生长，以便中厚皮片移植能取得可接受的功能和外观效果。
