Bakker V M, Swartberg P E, Heeley J D
J Dent Res. 1984 Feb;63(2):114-9. doi: 10.1177/00220345840630020301.
In order to determine the nature of tissue repair after removal of condyles, bilateral condylectomies were performed in seven growing female Macaca fascicularis. Two animals underwent condylectomies only, and five animals were fitted with maxillary and mandibular splints before undergoing condylectomies. One condyle from each condylectomized animal was processed for histologic examination. Four animals, with intact condyles, were available as controls: Two had splints placed, while the other two did not undergo any treatment. Nine mo after surgery, the histology of 12 resection sites and 12 control condyles (seven removed at condylectomy and five at death) was compared. In the control condyles, hypertrophic cartilage was seen over the entire condylar surface. From the 12 resection sites, five showed hypertrophic cartilage, non-hypertrophic cartilage cells were present in three, and four demonstrated bone apposition and resorption. Cartilage was present only at the medial and central aspects of the surgical site, and in every specimen, bone was seen at the lateral pole. Two out of 12 fossae overlying surgical sites contained hypertrophic cartilage, while the five control glenoid fossae showed bone, an intermediate zone, and a fibrous capsule. Because of the variety in tissue response and the small number of animals in each group, the effect of the splints could not be determined. Based on the results of this study, the following was concluded: (1) Regeneration of organized hypertrophic cartilage with inherent growth potential can take place after condylectomy, albeit not in every instance and only in the medial aspect of the stump. In the lateral aspect, and also medially if hypertrophic cartilage does not reform, bone is predominant. The original height is not recovered. (2) The cartilage of the glenoid fossa is capable of adaptive changes similar to those seen in condylar cartilage.
为了确定髁突切除术后组织修复的性质，对7只生长中的雌性食蟹猴进行了双侧髁突切除术。2只动物仅接受了髁突切除术，5只动物在进行髁突切除术之前佩戴了上颌和下颌夹板。对每只接受髁突切除的动物的一个髁突进行组织学检查。有4只髁突完整的动物作为对照：2只佩戴了夹板，另外2只未接受任何治疗。术后9个月，比较了12个切除部位和12个对照髁突（7个在髁突切除时切除，5个在动物死亡时切除）的组织学情况。在对照髁突中，整个髁突表面可见肥厚性软骨。在12个切除部位中，5个显示有肥厚性软骨，3个存在非肥厚性软骨细胞，4个表现出骨的附着和吸收。软骨仅存在于手术部位的内侧和中央部分，并且在每个标本中，外侧极可见骨组织。12个覆盖手术部位的关节窝中有2个含有肥厚性软骨，而5个对照关节盂显示有骨组织、中间带和纤维囊。由于组织反应的多样性以及每组动物数量较少，夹板的作用无法确定。基于本研究结果，得出以下结论：（1）髁突切除术后可发生具有内在生长潜力的有组织的肥厚性软骨再生，尽管并非在每种情况下都能发生，且仅发生在残端的内侧。在外侧，以及在内侧如果没有形成肥厚性软骨，则以骨组织为主。原始高度未恢复。（2）关节盂软骨能够发生类似于髁突软骨的适应性变化。
