Haier R J
Psychiatry Res. 1983 Nov;10(3):201-6. doi: 10.1016/0165-1781(83)90056-2.
Nonsuppression of cortisol following dexamethasone may identify a biologically homogeneous subgroup of psychiatric patients. This article reports two studies examining pain sensitivity and sensory inhibition measured by evoked potential augmenting/reducing in dexamethasone test (DST) suppressors and nonsuppressors. Since nonsuppression may be related to elevated levels of adrenocorticotropic hormone (ACTH) and, perhaps, endogenous opiates, pain sensitivity and augmenting/reducing may differ between suppressors and nonsuppressors. Results indicate that nonsuppressors lack sensory inhibition and that evoked potential augmenting/reducing is correlated strongly with pain sensitivity only in nonsuppressors. These results are consistent with the hypothesis that the DST identifies biologically different subgroups of depression.
地塞米松后皮质醇不被抑制可能可识别出精神疾病患者中一个生物学上同质的亚组。本文报告了两项研究，检测了地塞米松试验（DST）抑制者和非抑制者中通过诱发电位增强/减弱所测量的疼痛敏感性和感觉抑制。由于不被抑制可能与促肾上腺皮质激素（ACTH）水平升高以及或许与内源性阿片类物质有关，抑制者和非抑制者之间的疼痛敏感性和增强/减弱可能有所不同。结果表明，非抑制者缺乏感觉抑制，并且诱发电位增强/减弱仅在非抑制者中与疼痛敏感性密切相关。这些结果与以下假设一致，即DST可识别出抑郁症在生物学上不同的亚组。
