Robertson D M, Earle J, Anderson J A
Trans Ophthalmol Soc U K (1962). 1983;103 ( Pt 2):155-60.
When compared with Cobalt-60, the physical properties of Iodine-125 make it an attractive alternative therapy for consideration in the management of selected choroidal melanomas. The low-energy gamma emission can be nearly completely shielded by a thin sheet of gold 0.4 mm thick. Iodine-125 contained in a gold-backed episcleral plaque may reduce radiation exposure to non-target tissues of the eye including the optic nerve and macula. Iodine-125 is readily available, is adaptable to specific tumour locations and size, and offers very little radiation hazard to handlers. The physical characteristics of Iodine-125 are suitable for treatment of relatively large ocular tumours. Preliminary experience at the Mayo Clinic with Iodine-125 in the management of 12 patients with malignant melanoma to the choroid who have been followed between six months and two and a quarter years, indicate the effectiveness of Iodine-125 in promoting tumour shrinkage. In 11 of the 12 treated eyes, there is evidence of decreased tumour thickness as judged by ultrasonography and photography.
与钴-60相比，碘-125的物理特性使其成为治疗某些脉络膜黑色素瘤的一种有吸引力的替代疗法。低能γ射线几乎可以被一块0.4毫米厚的薄金片完全屏蔽。置于金背巩膜敷贴器中的碘-125可减少对眼部非靶组织（包括视神经和黄斑）的辐射暴露。碘-125易于获取，可根据肿瘤的具体位置和大小进行调整，且对操作人员的辐射危害极小。碘-125的物理特性适合治疗相对较大的眼部肿瘤。梅奥诊所对12例脉络膜恶性黑色素瘤患者使用碘-125进行治疗，并随访了6个月至2年零3个月，初步经验表明碘-125在促进肿瘤缩小方面是有效的。在12只接受治疗的眼睛中，有11只通过超声检查和摄影判断有肿瘤厚度减小的迹象。
