来自异质性人类结肠肿瘤的肿瘤亚群中的体外亚致死损伤修复
In vitro sublethal damage repair in tumour subpopulations from a heterogeneous human colon tumour.
作者信息
Leith J T, Vayer A V, De Wyngaert J K, Amols H, Peck R A, Glicksman A S
出版信息
Br J Cancer Suppl. 1984;6:207-11.
Abstract
The repair of sublethal radiation damage in two asynchronously growing tumour cell subpopulations (clones A and D) obtained from a single human adenocarcinoma biopsy specimen has been studied. The survival data found after generation of complete survival curves from split dose experiments in which exposures were separated by 3, 6, 12, or 24 h were examined. It was found that the method of performing irradiations (e.g., suspension cultures versus monolayer cultures) affected the shape of the single dose response curves, and as a result the interpretation of the amount of sublethal damage repair occurring after split dose irradiation.
摘要
对从一份人类腺癌活检标本中获得的两个异步生长的肿瘤细胞亚群（克隆A和克隆D）的亚致死性辐射损伤修复情况进行了研究。对在分割剂量实验中产生完整存活曲线后得到的存活数据进行了检查，在这些实验中，照射之间的间隔时间为3、6、12或24小时。结果发现，进行照射的方法（例如，悬浮培养与单层培养）会影响单剂量反应曲线的形状，因此也会影响对分割剂量照射后发生的亚致死性损伤修复量的解读。
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