单次剂量的5-（3,3-二甲基-1-三氮烯基）-咪唑-4-甲酰胺（DTIC）诱导的两种主要免疫反应的长期抑制。
Long-term depression of two primary immune responses induced by a single dose of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC).
作者信息
Puccetti P, Giampietri A, Fioretti M C
出版信息
Experientia. 1978 Jun 15;34(6):799-800. doi: 10.1007/BF01947335.
PMID:658308
Abstract
2 primary immune responses (anti-SRBC antibody response and allograft rejection) have been tested in mice at various time intervals after single doses of either DTIC or cyclophosphamide. The DTIC-induced immunodepression proved to be extremely long-lasting, being still detectable after 2 months.
摘要
在给小鼠单次注射达卡巴嗪（DTIC）或环磷酰胺后的不同时间间隔，对两种主要免疫反应（抗绵羊红细胞抗体反应和同种异体移植排斥反应）进行了检测。结果表明，DTIC诱导的免疫抑制作用持续时间极长，在2个月后仍可检测到。
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