Metabolic and morphologic changes induced by serotonin in skeletal muscle of rats after abdominal aorta ligation.

Myopatic changes observed in muscle of rats after abdominal aorta ligation and/or serotonin injection have been regarded as a suitable model to explore the possibility that vasoactive treatments induce muscular damage similar to human myopathies. In the present study, we investigated the effect of serotonin administration to normal and aorta-ligated rats on cAMP-dependent protein-kinase (PK) and hydrolytic enzymes in skeletal muscle.