Kelts K A, Kaiser K K
J Neurol Sci. 1979 Jan;40(1):23-7. doi: 10.1016/0022-510x(79)90005-4.
Support for the hypothesis that biogenic amines are involved in the production of muscle diseases comes from a report that rat muscle is damaged by combining distal aortic ligation with serotonin injection. Our studies explore the role of serotonin in the production of the myopathic changes in the aortic ligation-serotonin model. Twenty-six young Sprague-Dawley rats were subjected either to aortic ligation alone, aortic ligation followed by injection of serotonin (40 mg/kg, i.p.), or injection of serotonin alone. Following sacrifice 7--14 days later, 10 micrometer frozen sections of the soleus muscle were stained by trichrome, NADH-TR, and ATPase methods. Focal necrosis and phagocytosis or focal regeneration were seen after aortic ligation with, or without, subsequent serotonin injection. Serotonin alone produced only occasional mild changes in muscle. Therefore, we conclude that the significant damage to muscle in the ligation-serotonin model is provided by the aortic ligation, not the serotonin injection.
生物胺参与肌肉疾病产生这一假说的证据来源于一份报告，该报告称将远端主动脉结扎与血清素注射相结合会损害大鼠肌肉。我们的研究探讨了血清素在主动脉结扎-血清素模型中肌病变化产生过程中的作用。将26只年轻的斯普拉格-道利大鼠分别单独进行主动脉结扎、先进行主动脉结扎然后注射血清素（40毫克/千克，腹腔注射）或单独注射血清素。在7至14天后处死大鼠，用三色染色法、NADH-TR染色法和ATP酶染色法对比目鱼肌的10微米冰冻切片进行染色。在进行主动脉结扎后，无论随后是否注射血清素，均可见局灶性坏死、吞噬作用或局灶性再生。单独注射血清素仅偶尔会使肌肉产生轻微变化。因此，我们得出结论，结扎-血清素模型中对肌肉的显著损害是由主动脉结扎造成的，而非血清素注射。
