Adams M E
J Rheumatol Suppl. 1983 Dec;11:111-3.
Transection of the anterior cruciate ligament in the dog knee leads to a reproducible defined osteoarthritis (OA) with erosive cartilage loss, subchrondral sclerosis, and osteophyte formation, enabling studies of cartilage biochemistry before morphological changes are apparent. As early as 1 week after operation, menisci showed increased water content , 20% loss of galactosamine, and 40% loss of glucosamine. There was increased synthesis of larger proteoglycans (PG) at 3, 6, and 12 weeks, and the synthesis was greater in the menisci than the articular cartilage. there was no apparent impairment of the PG ability to aggregate with hyaluronate.
犬膝关节前交叉韧带横断会导致可重复性的典型骨关节炎（OA），出现侵蚀性软骨损失、软骨下硬化和骨赘形成，从而能够在形态学变化明显之前研究软骨生物化学。早在手术后1周，半月板就显示出水含量增加、半乳糖胺损失20%以及葡萄糖胺损失40%。在3周、6周和12周时，较大蛋白聚糖（PG）的合成增加，且半月板中的合成量大于关节软骨。PG与透明质酸聚集的能力没有明显受损。
