Duncan H
J Rheumatol Suppl. 1983 Dec;11:29-37.
Trabeculae and subchondral bone have been studied by scanning electron microscopy (EM) and fluorescence microscopy from joints removed surgically in patients with rheumatoid arthritis (RA), osteoarthritis (OA), and "normals" who had leg amputations with no primary arthritis. In the arthritic specimens, inflammation, bone damage and repair varied in different areas of the same joint. Osteoclasts and mononuclear cells were associated with areas of resorption--together and separately. Scanning EM showed trabeculae in RA to be thinner, narrower, fewer, and with spindle forms compared with thicker trabeculae in OA. Attempts at repair were more successful in OA despite the higher bone turnover which occurred locally at the rheumatoid joint.
通过扫描电子显微镜（EM）和荧光显微镜，对类风湿性关节炎（RA）、骨关节炎（OA）患者以及因非原发性关节炎行腿部截肢的“正常人”手术切除的关节中的小梁和软骨下骨进行了研究。在关节炎标本中，同一关节的不同区域炎症、骨损伤和修复情况各不相同。破骨细胞和单核细胞与吸收区域相关联——有时共同出现，有时单独出现。扫描电子显微镜显示，与OA中较厚的小梁相比，RA中的小梁更细、更窄、数量更少且呈纺锤形。尽管类风湿关节局部骨转换率较高，但OA的修复尝试更为成功。
