Leisen J C, Duncan H, Riddle J M, Pitchford W C
Division of Rheumatology, Henry Ford Hospital, Detroit, MI 48202.
J Rheumatol. 1988 Jan;15(1):17-22.
The junction between cellular pannus and cartilage/bone was identified grossly on rheumatoid metacarpal heads. Its topography was displayed by scanning electron microscopy using macerated samples. A uniform pattern of resorption bays, typical of osteoclastic activity, was seen spreading over the surfaces of both calcified cartilage and subchondral bone. The contact area between pannus and cartilage/bone was found to represent an erosive front. Morphologic evidence suggested that osteoclasts were primarily responsible for the destructive process.
在类风湿性掌骨头处大体上可识别出细胞性血管翳与软骨/骨之间的连接。通过使用浸软样本的扫描电子显微镜观察其地形。在钙化软骨和软骨下骨的表面均可见到一种典型破骨细胞活性的均匀吸收凹模式。发现血管翳与软骨/骨之间的接触区域代表一个侵蚀前沿。形态学证据表明破骨细胞是破坏过程的主要责任者。
