Klein A, Storch B, Beckerman A, Meyerson E, Colev S, Kaufmann H, Schachter A
J Natl Cancer Inst. 1984 Mar;72(3):605-7.
In previous studies we found that the plasma of carcinoma patients shows a reduced capacity to enhance lymphocytic cortisol metabolism. In the present study this capacity was assessed in the plasma of patients suffering from cervical carcinoma (Ce. Ca.) and of patients suffering from cervical dysplasia (Ce. Dis.) regarded as being at high risk to develop cancer. Known concentrations of human lymphocytes from healthy donors were incubated with cortisol in media containing 50% phosphate-buffered saline (PBS) and 50% of one of the following additions: 1) homologous plasma (HP), 2) plasma from the patients being tested or from healthy controls, or 3) additional PBS. The cortisol conversion rate was measured and compared with that obtained with lymphocytes immersed in HP. Previous findings showed that the plasma of cancer patients has a mean metabolism-enhancing rate 62% of that obtained with HP. In the present study the results were as follows: Ce. Ca., 60%; Ce. Dis., 70%: controls, 93%. The percentage of "cancer-positive" results were as follows: Ce. Ca., 91%; Ce. Dis., 45%; controls, 25%.
在先前的研究中，我们发现癌症患者的血浆增强淋巴细胞皮质醇代谢的能力降低。在本研究中，对被视为患癌高风险的宫颈癌（Ce. Ca.）患者和宫颈发育异常（Ce. Dis.）患者的血浆中的这种能力进行了评估。将已知浓度的来自健康供体的人淋巴细胞与皮质醇在含有50%磷酸盐缓冲盐水（PBS）和50%以下其中一种添加物的培养基中孵育：1）同源血浆（HP），2）受试患者或健康对照者的血浆，或3）额外的PBS。测量皮质醇转化率，并与将淋巴细胞浸入HP中所获得的转化率进行比较。先前的研究结果表明，癌症患者的血浆的平均代谢增强率为浸入HP中的淋巴细胞所获代谢增强率的62%。在本研究中，结果如下：宫颈癌患者，60%；宫颈发育异常患者，70%；对照组，93%。“癌症阳性”结果的百分比如下：宫颈癌患者，91%；宫颈发育异常患者，45%；对照组，25%。
