King R, Barchas J D, Huberman B A
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1244-7. doi: 10.1073/pnas.81.4.1244.
We report the results of the dynamics of a model of the central dopaminergic neuronal system. In particular, for certain values of a parameter k, which monitors the efficacy of dopamine at the postsynaptic receptor, chaotic solutions of the dynamical equations appear--a prediction that correlates with the observed increased variability in behavior among schizophrenics, the rapid fluctuations in motor activity among Parkinsonian patients treated chronically with L-dopa, and the lability of mood in some patients with an affective disorder. Moreover our hypothesis offers specific results concerning the appearance or disappearance of erratic solutions as a function of k and the external input to the dopamine neuronal system.
我们报告了中枢多巴胺能神经元系统模型的动力学结果。特别地，对于监测多巴胺在突触后受体处功效的参数k的某些值，动力学方程出现了混沌解——这一预测与精神分裂症患者行为中观察到的变异性增加、长期接受左旋多巴治疗的帕金森病患者运动活动的快速波动以及一些情感障碍患者的情绪不稳定相关。此外，我们的假设给出了关于作为k和多巴胺神经元系统外部输入函数的不稳定解的出现或消失的具体结果。
