Gibas Z, Becher R, Kawinski E, Horoszewicz J, Sandberg A A
Cancer Genet Cytogenet. 1984 Apr;11(4):399-404. doi: 10.1016/0165-4608(84)90020-7.
A high-resolution study of chromosomal rearrangements in a human prostatic cancer cell line, LNCaP, has been performed. The cytogenetic analysis revealed a pseudodiploid karyotype and the presence of seven marker chromosomes resulting from five aberrational events. The analysis of four clones derived from the original line showed a near-tetraploid chromosome number and the presence of the same seven markers observed in the original line. This is the first complete description of karyotypic rearrangements in a prostatic cancer cell line.
对人前列腺癌细胞系LNCaP中的染色体重排进行了一项高分辨率研究。细胞遗传学分析揭示了一个假二倍体核型以及由五个异常事件导致的七条标记染色体的存在。对源自原始细胞系的四个克隆进行分析，结果显示染色体数目接近四倍体，并且存在与原始细胞系中观察到的相同的七条标记染色体。这是对前列腺癌细胞系核型重排的首次完整描述。
