Bremme K, Eneroth P, Samuelson K
Gynecol Obstet Invest. 1984;17(3):120-6. doi: 10.1159/000299134.
Prostaglandin E2 (PGE2), but not oxytocin, treatment to induce parturition brought about an increase (p less than 0.001) in maternal serum levels of total estrogens (conjugated and nonconjugated estriol). There was no increase in nonconjugated estriol. To explore if the changes were related to an altered enterohepatic circulation, cholic acid assay in maternal serum was used. There were no changes in cholic acid which parallelled those in total estrogens. It is concluded that PGE2 does not appear to affect enterohepatic circulation of steroids, and it is suggested that the increase in total estrogens may be caused by changes in the kidney excretion of estriol.
用前列腺素E2（PGE2）而非催产素诱导分娩，可使母体血清中总雌激素（结合型和非结合型雌三醇）水平升高（p<0.001）。非结合型雌三醇无升高。为探究这些变化是否与肠肝循环改变有关，检测了母体血清中的胆酸。胆酸变化与总雌激素变化不平行。结论是PGE2似乎不影响类固醇的肠肝循环，提示总雌激素升高可能是雌三醇肾脏排泄变化所致。
