Foy H, Kondi A
J Natl Cancer Inst. 1984 Apr;72(4):941-8.
Eleven male baboons fed a synthetic diet completely lacking in riboflavin developed, after 15-36 weeks, profound macroscopic and microscopic architectural disorganization of the skin, mouth, and esophagus. The cutaneous lesions showed hyperkeratosis, gross derangement of keratinization with acanthosis, and impressive pseudocarcinomatous hyperplasia. In 5 baboons that died or were killed, there were large penetrating lesions having raised epithelial edges at the lower third of the esophagus or at the cardioesophageal junction, with gross epithelial hyperplasia and grossly deranged and thickened keratinization and numerous mitotic figures. None of the 8 control animals given riboflavin showed these abnormalities.
11只食用完全缺乏核黄素的合成饲料的雄性狒狒，在15 - 36周后，皮肤、口腔和食管出现了严重的宏观和微观结构紊乱。皮肤病变表现为角化过度、伴有棘皮症的明显角化紊乱以及显著的假癌性增生。在5只死亡或被处死的狒狒中，食管下三分之一处或食管胃交界处有大的穿透性病变，上皮边缘隆起，伴有明显的上皮增生、严重紊乱和增厚的角化以及大量有丝分裂象。8只给予核黄素的对照动物均未出现这些异常。
