Roe D A
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.
Semin Dermatol. 1991 Dec;10(4):293-5.
Mucocutaneous lesions are present in both acute and chronic riboflavin deficiency. The distribution of the lesions varies with the age and gender of the patient. Lesions of acute riboflavin deficiency are similar to those observed in protein-energy malnutrition of the kwashiorkor type. In chronic riboflavin deficiency the cutaneous lesions resemble monilial intertrigo and the mucous membrane lesions include a characteristic glossitis. Prompt resolution of lesions after therapeutic doses of the vitamin are given confirms the diagnosis. Biochemical changes caused by riboflavin deficiency, which explain the dermatoses and mucous membrane lesions, have not as yet been determined. Lack of information in this area is explained by the difficulty of separating cutaneous changes caused by the deficiency from those caused by trauma or other proximate etiologic agents.
急性和慢性核黄素缺乏均会出现皮肤黏膜病变。病变的分布因患者的年龄和性别而异。急性核黄素缺乏的病变与夸希奥科病型蛋白质 - 能量营养不良中观察到的病变相似。在慢性核黄素缺乏中，皮肤病变类似念珠菌性擦烂，黏膜病变包括特征性舌炎。给予治疗剂量的维生素后病变迅速消退可确诊。核黄素缺乏引起的生化变化可解释皮肤病和黏膜病变，但目前尚未确定。该领域信息匮乏是由于难以将缺乏引起的皮肤变化与创伤或其他近端病因引起的变化区分开来。
