Basu R, Chatterjee A
Fertil Steril. 1978 Jun;29(6):640-2.
The administration of pregnant mare's serum gonadotropin (PMSG), 30 IU on day 18 of pregnancy, resulted in premature labor in rats. However, this abortifacient efficacy of PMSG was not demonstrable when a simultaneous injection of progesterone, clomiphene, or indomethacin was scheduled, thus suggesting that the action of PMSG is medicated by the estrogen-stimulated release of prostaglandin. The termination of pseudopregnancy in bilaterally hysterectomized rats by PMSG and its reversal by indomethacin revealed that the inhibition of luteal function by PMSG does not require the presence of a uterus.
在妊娠第18天给大鼠注射30国际单位的孕马血清促性腺激素（PMSG）会导致早产。然而，当同时注射孕酮、氯米芬或吲哚美辛时，PMSG的这种堕胎作用无法得到证实，这表明PMSG的作用是通过雌激素刺激前列腺素的释放来介导的。PMSG可终止双侧子宫切除大鼠的假孕，而吲哚美辛可使其逆转，这表明PMSG对黄体功能的抑制并不需要子宫的存在。
