15-羟基二十碳四烯酸（15-HETE）在体内诱导的免疫抑制。

Immunosuppression induced in vivo by 15 hydroxyeicosatetraenoic acid (15 HETE).

作者信息

Aldigier J C, Gualde N, Mexmain S, Chable-Rabinovitch H, Ratinaud M H, Rigaud M

出版信息

Prostaglandins Leukot Med. 1984 Jan;13(1):99-107. doi: 10.1016/0262-1746(84)90109-4.

Abstract

We have investigated the in vivo effects of 15 HETE on C57Bl/6 (H-2b) mice injected IP daily with this product. After that the 15 HETE treated animals and the controls were challenged in vivo by DBA/2 (H-2d) cells. Splenocytes from 15 HETE injected animals were either stimulated in vitro by lectins or cocultivated with DBA/2 irradiated splenocytes. It was observed that the response of splenocytes from in vivo treated animals is weaker than the control's response. The data suggest that 15 HETE induce the generation of suppressor cells.

摘要

我们研究了15-羟基二十碳四烯酸（15 HETE）对每天腹腔注射该产品的C57Bl/6（H-2b）小鼠的体内作用。之后，用15 HETE处理的动物和对照组在体内受到DBA/2（H-2d）细胞的攻击。来自注射15 HETE动物的脾细胞要么在体外受到凝集素刺激，要么与经辐照的DBA/2脾细胞共培养。观察到体内处理动物的脾细胞反应比对照组的反应弱。数据表明15 HETE诱导了抑制性细胞的产生。