Duch D S, Woolf J H, Nichol C A, Davidson J R, Garbutt J C
Psychiatry Res. 1984 Feb;11(2):83-9. doi: 10.1016/0165-1781(84)90090-8.
Levels of urinary neopterin and biopterin were determined in patients having a diagnosis of schizophrenia, unipolar depression, or bipolar depression. Both neopterin and biopterin levels were significantly higher in the urine of patients with unipolar depression than in the urine of the control group. Subclassification of patients into primary and secondary depression demonstrated a significant elevation of urinary biopterin in both groups, whereas urinary neopterin was elevated only in those patients with primary depression. In patients with bipolar depression, neopterin excretion was elevated, but biopterin excretion did not differ from controls. No significant differences were found in schizophrenic patients.
对被诊断为精神分裂症、单相抑郁症或双相抑郁症的患者测定了尿新蝶呤和生物蝶呤水平。单相抑郁症患者尿液中的新蝶呤和生物蝶呤水平均显著高于对照组尿液中的水平。将患者分为原发性抑郁症和继发性抑郁症，结果显示两组患者的尿生物蝶呤均显著升高，而尿新蝶呤仅在原发性抑郁症患者中升高。双相抑郁症患者的新蝶呤排泄量升高，但生物蝶呤排泄量与对照组无差异。精神分裂症患者未发现显著差异。
