急性白血病中的尿糖蛋白：一种41000道尔顿的糖蛋白遵循细胞减少动力学。
Urinary glycoproteins in acute leukemias: a 41 000 dalton glycoprotein follows the kinetic of cytoreduction.
作者信息
Maubach P A, Emmerich B, Willer A, Ogilvie A, Rastetter J
出版信息
Blut. 1984 Apr;48(4):243-6. doi: 10.1007/BF00319817.
PMID:6585242
Abstract
Glycoproteins of leukemic cells and 24-hour urinary proteins were subjected to SDS polyacrylamide gel electrophoresis followed by affinity labelling I125 with Concanavalin A, indicating glycoproteins with mannose and/or glucose carbohydrate residues. Among the cellular glycoproteins a 41 000 dalton glycoprotein appeared under induction therapy in close correlation to the reduction of leukemic cells in ALL as well as in AML.
摘要
白血病细胞糖蛋白和24小时尿蛋白经十二烷基硫酸钠-聚丙烯酰胺凝胶电泳，然后用伴刀豆球蛋白A进行亲和标记I125，以显示含有甘露糖和/或葡萄糖碳水化合物残基的糖蛋白。在细胞糖蛋白中，一种41000道尔顿的糖蛋白在诱导治疗期间出现，这与急性淋巴细胞白血病和急性髓细胞白血病中白血病细胞的减少密切相关。
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