Mach M, Schneider U, Kersten W
Recent Results Cancer Res. 1983;84:413-20. doi: 10.1007/978-3-642-81947-6_31.
Evidence is presented showing a relation between polyamine concentration and the methylation of tRNA in vitro and in vivo. Polyamine excretion in urine of children with ALL and AML is slightly elevated before the commencement of chemotherapy. Immediately thereafter, excretion of acetylputrescine increases drastically over a period of at least 30-60 days. The elevation seems to be caused by different factors, e.g., destruction of tumor cells, induction of ornithindecarboxylase, and cell recovery after termination of chemotherapy. Acetylspermidine excretion also increases 3-4 days after the beginning of chemotherapy. A positive correlation exists between leukocyte counts and excretion of acetylspermidine. The ratio of acetylspermidine excretion at days 3-4 of the therapy to that before commencement of chemotherapy could be an indicator of response to the therapy.
有证据表明，在体外和体内，多胺浓度与tRNA甲基化之间存在关联。急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）患儿在化疗开始前尿中多胺排泄略有升高。此后，乙酰腐胺的排泄在至少30 - 60天的时间内急剧增加。这种升高似乎是由不同因素引起的，例如肿瘤细胞的破坏、鸟氨酸脱羧酶的诱导以及化疗结束后的细胞恢复。乙酰亚精胺排泄在化疗开始后3 - 4天也会增加。白细胞计数与乙酰亚精胺排泄之间存在正相关。治疗第3 - 4天的乙酰亚精胺排泄与化疗开始前的排泄之比可能是治疗反应的一个指标。
