通过测量胫骨骨断裂应变评估大鼠维生素A过多症。

Evaluation of hypervitaminosis A in the rat by measurement of tibial bone breaking strain.

作者信息

Cashin C H, Lewis E J

出版信息

J Pharmacol Methods. 1984 Apr;11(2):91-5. doi: 10.1016/0160-5402(84)90018-4.

Abstract

Using etretinate as a model compound, the bone changes characteristic of hypervitaminosis A were evaluated in the rat in terms of tibial bone-breaking strain. Dose-related effects were observed in the dose range of 5-30 mg/kg p.o. for 15 days. The model proved a simple and precise means of assessing hypervitaminosis A in this species. Isotretinoin also showed a small but significant reduction in tibial breaking strain, but with a shallow dose-response curve in the range of 50-150 mg/kg.

摘要

以依曲替酯作为模型化合物，根据胫骨骨折应变评估大鼠维生素A过多症的骨骼变化特征。口服给予剂量为5 - 30 mg/kg，持续15天，观察到了剂量相关效应。该模型被证明是评估该物种维生素A过多症的一种简单而精确的方法。异维A酸也使胫骨骨折应变略有但显著降低，但在50 - 150 mg/kg范围内剂量反应曲线较平缓。