Debeljuk L, Khar A, Jutisz M
Mol Cell Endocrinol. 1978 Apr;10(2):159-62. doi: 10.1016/0303-7207(78)90122-3.
A culture of dispersed rat anterior pituitary cells was used to test the ability of pimozide and sulpiride to affect the basal gonadotropin release and their effects on the response to Gn-RH. Sulpiride did not alter either the basal or the Gn-RH-induced release of LH, and the lowest dose (500 ng/ml) seemed to potentiate the Gn-RH-induced FSH release. On the other hand, both doses of pimozide (100 ng/ml and 10 microgram/ml) significantly inhibited the release of FSH and LH induced by Gn-RH but did not affect the basal release of the two gonadotropins. From these results it is evident that pimozide, at the doses used, is a powerful inhibitor of the pituitary response to Gn-RH in vitro. Sulpiride on the other hand had no effect on the pituitary response to Gn-RH in vitro, except on FSH release, using the lower dose.
采用分散的大鼠垂体前叶细胞培养物来测试匹莫齐特和舒必利影响基础促性腺激素释放的能力及其对促性腺激素释放激素（Gn-RH）反应的影响。舒必利既不改变基础状态下的LH释放，也不改变Gn-RH诱导的LH释放，且最低剂量（500 ng/ml）似乎能增强Gn-RH诱导的FSH释放。另一方面，两种剂量的匹莫齐特（100 ng/ml和10 μg/ml）均显著抑制Gn-RH诱导的FSH和LH释放，但不影响这两种促性腺激素的基础释放。从这些结果可以明显看出，在所使用的剂量下，匹莫齐特在体外是垂体对Gn-RH反应的强力抑制剂。另一方面，舒必利在体外对垂体对Gn-RH的反应没有影响，但使用较低剂量时对FSH释放有影响。
