Santolaya R C, Ciocca D, Maneschi E
Cell Tissue Res. 1979 Jul 17;199(3):483-92. doi: 10.1007/BF00236084.
The effects of pimozide, a dopamine receptor-blocking agent, were studied in the pars distalis of the rat. The animals received 100 micrograms/100 g pimozide daily for 5, 10, 15, and 20 days. Pimozide induces striking ultrastructural changes after 5 days of treatment. The number of luteotroph (LTH) cells is signficantly increased; they display characteristics of stimulation. The extrusion of granules into the intercellular space via exocytosis is frequently observed. The intercellular spaces are highly dilated, forming a lacunar system filled with an amorphous material, erythrocytes and involuted LTH cells. Transitional stages in the process of involution are observed in LTH cells. Luteotroph cells also form a syncytium. Twenty days after treatment the above-described changes decrease in magnitude. The present findings suggest that pimozide stimulates the mechanism of synthesis and release in the luteotroph cells, an effect that is less evident with longer treatment.
研究了多巴胺受体阻断剂匹莫齐特对大鼠远侧部的影响。动物每日接受100微克/100克匹莫齐特，持续5、10、15和20天。治疗5天后，匹莫齐特可引起明显的超微结构变化。促黄体生成素（LTH）细胞数量显著增加；它们表现出受刺激的特征。经常观察到颗粒通过胞吐作用挤入细胞间隙。细胞间隙高度扩张，形成一个充满无定形物质、红细胞和退化LTH细胞的腔隙系统。在LTH细胞中观察到退化过程中的过渡阶段。促黄体生成素细胞也形成合体细胞。治疗20天后，上述变化的程度降低。目前的研究结果表明，匹莫齐特刺激促黄体生成素细胞的合成和释放机制，随着治疗时间延长，这种作用不太明显。
