Ganda O P, Day J L, Soeldner J S, Connon J J, Gleason R E
Diabetes. 1978 Jul;27(7):715-25. doi: 10.2337/diab.27.7.715.
We have developed a methodology for measuring the reproducibility of the oral glucose tolerance test (OGTT) and the intravenous glucose tolerance test (IVGTT) in normal subjects and in offspring of conjugal diabetic parents. Both groups of subjects revealed more striking correlations of several parameters of blood glucose and insulin secretion between two IVGTTs than between two OGTTs. Employing arbitrary criteria, we calculated a "reproducibility index" as a quantitative measure of blood glucose variability in each subject. No significant difference was found in the reproducibility of OGTT versus IVGTT, nor in normals versus the offspring. Only about 50 per cent of the tests in normals and in the offspring could be considered to be "reproducible." The offspring revealed greater correlations of several parameters, particularly insulin secretion, between the two IVGTTs and between the two OGTTs as compared with the normal group. However, the blood glucose variations tended to be considerably greater in the offspring from one to the other test.
我们已经开发出一种方法，用于测量正常受试者以及双亲患糖尿病的后代口服葡萄糖耐量试验（OGTT）和静脉葡萄糖耐量试验（IVGTT）的可重复性。两组受试者中，两次IVGTT之间血糖和胰岛素分泌的几个参数的相关性比两次OGTT之间更为显著。采用任意标准，我们计算了一个“可重复性指数”，作为每个受试者血糖变异性的定量指标。OGTT和IVGTT的可重复性之间，以及正常人与后代之间均未发现显著差异。正常人和后代中只有约50%的测试可被认为是“可重复的”。与正常组相比，后代两次IVGTT之间以及两次OGTT之间的几个参数，尤其是胰岛素分泌的相关性更高。然而，后代在两次测试之间的血糖变化往往要大得多。
