Ogihara Y, Sekiguchi K, Tsuruta T
Cancer. 1984 Jun 15;53(12):2615-8. doi: 10.1002/1097-0142(19840615)53:12<2615::aid-cncr2820531208>3.0.co;2-s.
A unique case of a 15-year-old boy with complete paraplegia due to the compression of osteogenic sarcoma at the fourth thoracic vertebra is presented. Because of the difficulty of surgical treatment, he was treated merely by the arterial infusion of Adriamycin (doxorubicin) and systemic chemotherapy in conformity with the cyclophosphamide, Oncovin (vincristine), methotrexate, phenylalanine mustard, Adriamycin (doxorubicin) ( COMPADRI )-III regimen. The patient regained normal function, and has been disease-free without any neurologic deficit for 6 years. There appears to be some hope for cure using chemotherapy only in otherwise unpromising patients.
本文报告了一例独特的病例,一名15岁男孩因第四胸椎骨肉瘤压迫导致完全性截瘫。由于手术治疗困难,他仅接受了阿霉素(多柔比星)动脉灌注以及符合环磷酰胺、长春新碱、甲氨蝶呤、苯丙氨酸氮芥、阿霉素(多柔比星)(COMPADRI)-III方案的全身化疗。患者恢复了正常功能,并且6年来一直无病,没有任何神经功能缺损。对于其他治疗前景不佳的患者,仅使用化疗似乎有治愈的希望。