Abdel-Galil A M, Wrba H, El-Mofty M M
Exp Pathol. 1984;25(2):97-102. doi: 10.1016/s0232-1513(84)80014-6.
Two retinoids (13-cis-retinoic acid and retinyl palmitate ) have been shown to exert a good preventive effect in chemically induced papillomas and carcinomas of the skin in female Swiss mice; this effect was investigated over a period of 23 weeks. The tumors were induced by repeated topical application of 3-methylcholanthrene (0.3% MCA, dissolved in acetone; 14 applications). Retinyl palmitate (RP; 6 mg in 0.1 ml acetone/mouse; 10 applications) and 13-cis-retinoic acid (RA; 3 mg in 0.1 ml acetone/mouse; 10 applications) were also administered topically for the 3rd to 9th week from the start of the experiment. This investigation gave evidence for the fact that both the retinoids did not only inhibit the development of skin papillomas but had also a marked effect on skin carcinomas.
两种类视黄醇（13-顺式视黄酸和棕榈酸视黄酯）已被证明对雌性瑞士小鼠皮肤化学诱导的乳头状瘤和癌具有良好的预防作用；在23周的时间里对这种作用进行了研究。通过反复局部涂抹3-甲基胆蒽（0.3% MCA，溶于丙酮；涂抹14次）诱导肿瘤。从实验开始的第3周到第9周，也局部给予棕榈酸视黄酯（RP；每只小鼠6毫克溶于0.1毫升丙酮；涂抹10次）和13-顺式视黄酸（RA；每只小鼠3毫克溶于0.1毫升丙酮；涂抹10次）。这项研究证明了这样一个事实，即这两种类视黄醇不仅抑制皮肤乳头状瘤的发展，而且对皮肤癌也有显著作用。
