Oberhaensli R D, Mueller R M, Fridrich R
J Nucl Med. 1984 Jun;25(6):668-72.
The contrast-enhancing properties of iron (Fe) and deferoxamine (DFO) in abscess imaging with Ga-67 citrate were compared in rats bearing turpentine-induced abscesses. Iron administration shifted Ga-67 from plasma into tissues such as muscle and fat. As a result, the abscess-to-plasma ratio increased whereas the abscess-to-muscle ratio decreased. DFO enhanced the abscess-to-muscle and abscess-to-plasma ratios by increasing urinary Ga-67 excretion. In contrast to Fe, DFO removed abscess-bound Ga-67, thus representing a disadvantage of DFO compared with Fe. As a result, the abscess-to-plasma ratio was more effectively enhanced by Fe than by DFO. We conclude that abscess imaging with Ga-67 citrate may be improved by administration of Fe for detection of abscesses masked by blood activity, or DFO for detection of abscesses surrounded by muscle tissue.
在患有松节油诱导脓肿的大鼠中，比较了铁（Fe）和去铁胺（DFO）在枸橼酸镓-67脓肿成像中的对比增强特性。给予铁后，镓-67从血浆转移到肌肉和脂肪等组织中。结果，脓肿与血浆的比值增加，而脓肿与肌肉的比值降低。DFO通过增加尿中镓-67的排泄来提高脓肿与肌肉以及脓肿与血浆的比值。与铁不同，DFO会去除脓肿结合的镓-67，因此与铁相比，这是DFO的一个缺点。结果，铁比DFO更有效地提高了脓肿与血浆的比值。我们得出结论，对于检测被血液活性掩盖的脓肿，给予铁可能会改善枸橼酸镓-67脓肿成像；对于检测被肌肉组织包围的脓肿，给予DFO可能会改善成像。
