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铁载体作为工具和治疗手段。

Siderophores as tools and treatments.

作者信息

Gräff Á Tamás, Barry Sarah M

机构信息

Department of Chemistry, Faculty of Natural, Mathematical and Engineering Sciences, King's College London, Britannia House, London, SE1 1DB UK.

出版信息

NPJ Antimicrob Resist. 2024;2(1):47. doi: 10.1038/s44259-024-00053-4. Epub 2024 Dec 5.

DOI:10.1038/s44259-024-00053-4
PMID:39649077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11621027/
Abstract

In the search for iron, an essential element in many biochemical processes, microorganisms biosynthesise dedicated chelators, known as siderophores, to sequester iron from their environment and actively transport the siderophore complex into the cell. This process has been implicated in bacterial pathogenesis and exploited through siderophore-antibiotic conjugates as a method for selective antibiotic delivery. Here we review this Trojan-horse approach including design considerations and potential in diagnostics and infection imaging.

摘要

在寻找铁（许多生物化学过程中的必需元素）的过程中，微生物生物合成专门的螯合剂，即铁载体，以从其环境中螯合铁，并将铁载体复合物主动转运到细胞中。这一过程与细菌致病性有关，并通过铁载体-抗生素缀合物作为一种选择性抗生素递送方法加以利用。在此，我们综述这种特洛伊木马方法，包括设计考量以及在诊断和感染成像方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/da6ba98610ee/44259_2024_53_Fig12_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/da6ba98610ee/44259_2024_53_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/2d6efaafce34/44259_2024_53_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/881d24795b41/44259_2024_53_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/9c5491be1204/44259_2024_53_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/5a653ea13ea3/44259_2024_53_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/ca47c73ba305/44259_2024_53_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/3767af681404/44259_2024_53_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/588859b8dc81/44259_2024_53_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/f0116410cc8f/44259_2024_53_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/d818bc9a548a/44259_2024_53_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/159079a9182e/44259_2024_53_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/8b44825f9d06/44259_2024_53_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abd/11721444/da6ba98610ee/44259_2024_53_Fig12_HTML.jpg

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ACS Infect Dis. 2024 Apr 12;10(4):1250-1266. doi: 10.1021/acsinfecdis.3c00686. Epub 2024 Mar 4.
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Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria.儿茶酚-铁载体模拟物将核酸治疗药物递送入细菌。
Angew Chem Int Ed Engl. 2024 May 6;63(19):e202402405. doi: 10.1002/anie.202402405. Epub 2024 Mar 11.
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A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling.
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Siderophore specificities of the Pseudomonas aeruginosa TonB-dependent transporters ChtA and ActA.铜绿假单胞菌中与TonB相关的转运蛋白ChtA和ActA的铁载体特异性。
FEBS Lett. 2023 Dec;597(23):2963-2974. doi: 10.1002/1873-3468.14740. Epub 2023 Oct 6.
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