Lee E C, Tu R S, Fantone J C, Varani J
Oncology. 1984;41(3):210-6. doi: 10.1159/000225825.
The effects of phorbol esters on five murine cell lines were examined. In three of these lines, all of which were highly malignant, phorbol ester treatment induced motility and foreign surface adherence while concomitantly inhibiting proliferation. In two other, nonmalignant cell lines phorbol ester treatment stimulated proliferation but did not influence motility or adherence. Possible roles for prostaglandins in these responses were investigated. The mitogenic effects of the phorbol esters were duplicated by prostaglandin F2 alpha. In contrast, prostaglandin E1 and prostacyclin inhibited proliferation induced by the phorbol esters. These agents also inhibited phorbol ester-induced cell motility.
研究了佛波酯对五种小鼠细胞系的影响。在其中三种均为高度恶性的细胞系中，佛波酯处理诱导了细胞运动性和对外表面的黏附，同时抑制了细胞增殖。在另外两种非恶性细胞系中，佛波酯处理刺激了细胞增殖，但未影响细胞运动性或黏附。研究了前列腺素在这些反应中的可能作用。前列腺素F2α可复制佛波酯的促有丝分裂作用。相反，前列腺素E1和前列环素抑制佛波酯诱导的细胞增殖。这些药物还抑制佛波酯诱导的细胞运动性。
