Delescluse C, Fürstenberger G, Marks F, Pruniéras M
Cancer Res. 1982 May;42(5):1975-9.
In cultures of basal epidermal cells obtained from ear skin of adult guinea pigs, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate induces cellular proliferation which is prostaglandin dependent and inhibited by indomethacin. Inhibition by indomethacin can be overcome by prostaglandins E2 and F2 alpha, with prostaglandin F2 alpha being more effective. The concomitant induction of ornithine decarboxylase activity is insensitive to indomethacin inhibition. The nonpromoting derivative 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate evokes a prostaglandin-independent, i.e., indomethacin-insensitive, stimulation of cell proliferation without inducing ornithine decarboxylase activity.
在从成年豚鼠耳部皮肤获取的基底表皮细胞培养物中，促肿瘤佛波酯12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯可诱导细胞增殖，这种增殖依赖于前列腺素且受吲哚美辛抑制。吲哚美辛的抑制作用可被前列腺素E2和F2α克服，其中前列腺素F2α更有效。同时诱导的鸟氨酸脱羧酶活性对吲哚美辛抑制不敏感。非促肿瘤衍生物4 - O - 甲基 - 12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯可引发不依赖前列腺素（即对吲哚美辛不敏感）的细胞增殖刺激，且不诱导鸟氨酸脱羧酶活性。
