Bergren D R, Gustafson J M, Myers D L
Prostaglandins. 1984 Mar;27(3):391-405. doi: 10.1016/0090-6980(84)90198-9.
Pulmonary rapidly-adapting-receptors ( RARs ) are sensory nerve endings whose afferent fibers can be recorded in the vagus nerve. RARs may play a role in reflex bronchoconstriction as seen in anaphylaxis. They can be stimulated by chemical mediators of anaphylaxis, such as prostaglandin F2 alpha (PGF2 alpha). PGF2 alpha aerosol was administered to saline and bovine serum albumin (BSA)-treated guinea pigs while recording the activity of RARs . PGF2 alpha (250 micrograms/ml) given for 7-13 minutes increased both tracheal pressure and nerve activity over that produced by saline exposure in untreated guinea pigs. PGF2 alpha administered for three minutes (5-100 micrograms/ml) increased RAR nerve activity in a dose-related manner in the first five minutes of the experiment only in the BSA treated guinea pigs. Since changes in tracheal pressure did not show a significant dose-response relationship, the RARs responding to PGF2 alpha seemed to be stimulated by a direct mechanism. No correlation was shown between tracheal pressure and RAR nerve activity during PGF2 alpha treatment. Whereas, a significant correlation was found between tracheal pressure and RAR nerve activity during histamine aerosol treatment (r = 0.985). Histamine aerosol (1 to 1000 micrograms/ml, 3 min.) increased intratracheal pressure for 3 out of 4 doses. RAR nerve activity increased significantly only at the highest dose. Therefore, a possible direct effect of PGF2 alpha upon RARs exists while the effect of histamine seems dependent upon changes in airway pressure in the guinea pig.
肺快速适应感受器（RARs）是感觉神经末梢，其传入纤维可在迷走神经中记录到。RARs可能在过敏反应中所见的反射性支气管收缩中起作用。它们可被过敏反应的化学介质刺激，如前列腺素F2α（PGF2α）。在记录RARs活性的同时，将PGF2α气雾剂给予生理盐水处理和牛血清白蛋白（BSA）处理的豚鼠。给予PGF2α（250微克/毫升）7 - 13分钟，与未处理的豚鼠暴露于生理盐水相比，气管压力和神经活性均增加。仅在BSA处理的豚鼠中，给予PGF2α三分钟（5 - 100微克/毫升）在实验的前五分钟内以剂量相关方式增加了RAR神经活性。由于气管压力变化未显示出显著的剂量 - 反应关系，对PGF2α作出反应的RARs似乎是通过直接机制被刺激的。在PGF2α处理期间，气管压力与RAR神经活性之间未显示出相关性。然而，在组胺气雾剂处理期间，气管压力与RAR神经活性之间发现了显著相关性（r = 0.985）。组胺气雾剂（1至1000微克/毫升，3分钟）在4个剂量中有3个剂量增加了气管内压力。RAR神经活性仅在最高剂量时显著增加。因此，PGF2α对RARs可能存在直接作用，而组胺的作用似乎取决于豚鼠气道压力的变化。
