Sadick N, Roubin G S, Harris P J, Hiroe M, Meares S, Bautovich G, Kelly D T
Acta Med Scand Suppl. 1984;681:91-8. doi: 10.1111/j.0954-6820.1984.tb08682.x.
The effects of intravenous Verapamil (V) on exercise haemodynamics and ventricular function were compared in 13 patients with stable effort angina. Intravascular pressures, thermodilution cardiac output and radionuclide ejection fraction were measured simultaneously at rest and during exercise. At rest Verapamil produced systemic vasodilation. During exercise at identical workloads compared to control, Verapamil increased cardiac index (CI) and decreased AVO2 difference. Pulmonary artery wedge pressure was lower. Ejection fraction was higher (control-55 +/- 11% vs V-64 +/- 11%) as the disproportionate increase in end systolic volume relative to the end diastolic volume was prevented. Verapamil is effective in exercise induced angina and alters haemodynamics primarily through its vasodilating properties associated with an increased CI.
在13例稳定型劳力性心绞痛患者中，比较了静脉注射维拉帕米（V）对运动血流动力学和心室功能的影响。在静息和运动期间同时测量血管内压力、热稀释心输出量和放射性核素射血分数。静息时，维拉帕米可引起全身血管舒张。与对照组相比，在相同工作量的运动期间，维拉帕米增加了心脏指数（CI），并降低了动静脉血氧含量差。肺动脉楔压较低。射血分数较高（对照组为55±11%，维拉帕米组为64±11%），因为收缩末期容积相对于舒张末期容积的不成比例增加得到了预防。维拉帕米对运动诱发的心绞痛有效，主要通过其与CI增加相关的血管舒张特性改变血流动力学。
