Levine M, Parker D E, Stober J A
Arch Oral Biol. 1984;29(3):191-4. doi: 10.1016/0003-9969(84)90053-0.
Adults aged 20-38 years were classified by a positive (+) or negative (-) precipitating serum antibody response to D-alanyl glycerol teichoic acid (S), or an antigen from Actinomyces spp. (A). Culture filtrates of Streptococcus mutans and Actinomyces viscosus were used to detect the respective specific antibodies by immunoelectrophoresis and immunodiffusion when present in serum at a concentration of more than 0.05 mg/ml. Among subjects who had grown up in fluoridated areas, A+ subjects exhibited significantly fewer decayed, missing and filled teeth or teeth surfaces compared to A- subjects (p less than 0.02). For the whole population examined, caries severity increased with age and decreased with length of residence in a fluoridated area (p less than 0.01). When classified by A and S antibody response, only S-subjects showed a significant increase in caries score with age (p less than 0.02) and only A+S+ subjects a significant decrease in score with length of exposure to fluoridated water (p less than 0.05). It is concluded that the severity of caries in relation to age and fluoride exposure may differ in subjects with the different antibody specificities.
20至38岁的成年人根据其对D-丙氨酰甘油磷壁酸（S）或放线菌属抗原（A）的血清沉淀抗体反应呈阳性（+）或阴性（-）进行分类。当血清中变形链球菌和粘性放线菌的培养滤液浓度超过0.05mg/ml时，通过免疫电泳和免疫扩散来检测各自的特异性抗体。在氟化物地区长大的受试者中，与A-受试者相比，A+受试者的龋齿、缺失和填充牙或牙面明显更少（p<0.02）。对于所有接受检查的人群，龋齿严重程度随年龄增加而增加，随在氟化物地区居住时间的延长而降低（p<0.01）。按A和S抗体反应分类时，只有S-受试者的龋齿评分随年龄显著增加（p<0.02），只有A+S+受试者的评分随接触氟化物水的时间延长而显著降低（p<0.05）。得出的结论是，具有不同抗体特异性的受试者中，与年龄和氟化物暴露相关的龋齿严重程度可能有所不同。
