Jacobs A D, Gale R P
Cancer Treat Rep. 1984 Jun;68(6):909-11.
Patients receiving ionizing radiation therapy or cytotoxic chemotherapy are at increased risk of developing acute myelogenous leukemia. Ten cases of therapy-linked myelogenous leukemia have been reported in patients with sarcoma, and we report here the first case in a patient who received combined-modality therapy for treatment of an osteogenic sarcoma. As treatment for this disease becomes more intensive and survival improves, the incidence of leukemia following therapy for osteogenic sarcoma may increase.
接受电离辐射治疗或细胞毒性化疗的患者发生急性髓系白血病的风险增加。已有10例肉瘤患者发生与治疗相关的髓系白血病的报道，我们在此报告首例接受综合治疗的骨肉瘤患者发生该病的病例。随着这种疾病的治疗变得更加强化且生存率提高，骨肉瘤治疗后白血病的发病率可能会增加。
