Vasil'ev V Iu, Dorofeev G I, Ivashkin V T, Sultanov V K, Romanov V V
Biull Eksp Biol Med. 1984 Jun;97(6):717-9.
Protein kinase, cAMP-dependent and casein kinase activities and the ratio of these activities were determined in normal and neoplastic tissues of the colonic mucosa. Substantial activation of casein kinase and an appropriate decrease in the activity ratio of the enzymes were revealed in the malignant tissue. Protein kinase activity changed in a similar fashion in the histologically intact mucosa located 25-30 cm from the center of the tumor. The data obtained are suggestive of the possibility of using the above-indicated findings for the biochemical diagnosis of malignant neoplasms.
在结肠黏膜的正常组织和肿瘤组织中测定了蛋白激酶、环磷酸腺苷依赖性激酶活性以及酪蛋白激酶活性，还有这些活性的比值。结果显示，恶性组织中酪蛋白激酶有显著激活，且酶活性比值适当降低。在距离肿瘤中心25 - 30厘米处组织学完整的黏膜中，蛋白激酶活性也有类似变化。所获数据表明，上述发现有可能用于恶性肿瘤的生化诊断。
