Aleksandrov V B, Levitan M Kh, Minaev B N, Eshba I R, Vasil'ev V Iu
Vopr Onkol. 1986;32(8):45-53.
The cAMP level and the activity of cAMP-dependent and independent protein kinases were measured in adenomatous polyps, villous polyps (premalignant condition) and adenocarcinomas. The cAMP concentration and ratio of cAMP level versus cAMP-independent casein kinase activity were significantly lower in adenocarcinomas compared to adenomatous polyps, thus permitting differentiation between benign and malignant lesions. The cAMP versus cAMP-dependent histone kinase level ratio was used as a test for differentiation between malignancies and premalignant condition. It was markedly lower in adenocarcinomas than in villous polyps.
在腺瘤性息肉、绒毛状息肉（癌前病变）和腺癌中测量了环磷酸腺苷（cAMP）水平以及依赖cAMP和不依赖cAMP的蛋白激酶活性。与腺瘤性息肉相比，腺癌中的cAMP浓度以及cAMP水平与不依赖cAMP的酪蛋白激酶活性之比显著降低，从而能够区分良性和恶性病变。cAMP与依赖cAMP的组蛋白激酶水平之比被用作区分恶性肿瘤和癌前病变的检测指标。腺癌中的该比值明显低于绒毛状息肉。
