Morel C, Vergnaud M, Langeard M, Benard Y
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):516-9.
Pefloxacin is a new quinolone with significant in vitro antibacterial activity and a broad spectrum. It was included in an extensive study of antibiotic diffusion into bronchial mucus. Pefloxacin was given to 35 patients divided into five groups according to the timing of sputum sampling. Plasma specimens were taken simultaneously. Pefloxacin was measured by microbiological assay. Mean pefloxacin concentrations in bronchial mucus was high, exceeding 5 mg/l. Concentrations on the first and third days were similar. The ratio of mucus concentrations to plasma concentrations was high in each case, around or often above 1. These findings show that diffusion of pefloxacin into bronchial mucus is outstanding.
培氟沙星是一种新型喹诺酮类药物，具有显著的体外抗菌活性且抗菌谱广。它被纳入了一项关于抗生素向支气管黏液扩散的广泛研究。根据痰液采样时间，将35例患者分为五组，并给予培氟沙星治疗。同时采集血浆样本。采用微生物测定法测定培氟沙星。支气管黏液中培氟沙星的平均浓度较高，超过5mg/l。第一天和第三天的浓度相似。在每种情况下，黏液浓度与血浆浓度之比都很高，约为1或经常高于1。这些研究结果表明，培氟沙星向支气管黏液的扩散非常显著。
