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1
Penetration of pefloxacin into bronchial secretions.培氟沙星在支气管分泌物中的渗透情况。
Antimicrob Agents Chemother. 1989 Mar;33(3):391-3. doi: 10.1128/AAC.33.3.391.
2
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4
Penetration of ciprofloxacin in bronchial secretions after intravenous administration.
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[penetration of fosfomycin into bronchial secretions].
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Penetration of cefsulodin into bronchial secretions.头孢磺啶在支气管分泌物中的渗透情况。
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引用本文的文献

1
Pefloxacin clinical pharmacokinetics.培氟沙星的临床药代动力学。
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本文引用的文献

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[Clofibrate pharmacokinetics in chronic renal failure (author's transl)].氯贝丁酯在慢性肾功能衰竭中的药代动力学（作者译）
Therapie. 1980 Nov-Dec;35(6):705-16.
2
Erythromycin and bromhexine in acute exacerbations of chronic bronchitis. A study on sputum penetration and clinical effectiveness.
Eur J Respir Dis. 1982 Jul;63(4):325-9.
3
[Pefloxacine: diffusion into bronchial mucus].[培氟沙星：在支气管黏液中的扩散]
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):516-9.
4
Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans.甲磺酸培氟沙星在小鼠、大鼠、犬、猴及人体内的吸收、分布、代谢转归及消除
Antimicrob Agents Chemother. 1984 Apr;25(4):463-72. doi: 10.1128/AAC.25.4.463.
5
In vitro activity of pefloxacin compared to that of quinolones and other antimicrobial agents.
Chemioterapia. 1984 Aug;3(4):235-41.
6
Endobronchial Polymyxin B: experimental observations in chronic bronchitis.支气管内多粘菌素B：慢性支气管炎的实验观察
Chest. 1970 Oct;58(4):352-7. doi: 10.1378/chest.58.4.352.
7
Penetration of aztreonam into human bronchial secretions.氨曲南在人支气管分泌物中的渗透情况。
Antimicrob Agents Chemother. 1985 Feb;27(2):263-4. doi: 10.1128/AAC.27.2.263.
8
Pefloxacin in acute exacerbations of chronic bronchitis.培氟沙星用于慢性支气管炎急性加重期。
J Antimicrob Chemother. 1985 Sep;16(3):379-88. doi: 10.1093/jac/16.3.379.
9
Improved high-performance liquid chromatographic determination of pefloxacin and its metabolite norfloxacin in human plasma and tissue.改进的高效液相色谱法测定人血浆和组织中的培氟沙星及其代谢产物诺氟沙星。
J Chromatogr. 1985 Apr 12;339(1):214-8. doi: 10.1016/s0378-4347(00)84647-2.
10
Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients.重症监护病房中插管患者医院获得性肺炎的诊断
Am Rev Respir Dis. 1987 Feb;135(2):426-32. doi: 10.1164/arrd.1987.135.2.426.

培氟沙星在支气管分泌物中的渗透情况。

Penetration of pefloxacin into bronchial secretions.

作者信息

Bonmarchand G, Grès J J, Lerebours G, Massari P, Mayoux J J, Montay A, Leroy J

机构信息

Intensive Care Unit, Charles-Nicolle Hospital, Rouen, France.

出版信息

Antimicrob Agents Chemother. 1989 Mar;33(3):391-3. doi: 10.1128/AAC.33.3.391.

DOI:10.1128/AAC.33.3.391
PMID:2729932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171499/
Abstract

Twelve patients, intubated for acute exacerbation of chronic obstructive pulmonary disease, received six intravenous doses of 400 mg of pefloxacin at 12-h intervals. Samples of blood and bronchial secretions were taken simultaneously, before the injection and at 0.5, 3, 6, 9, and 12 h after the end of the sixth infusion. There was a large variation in pefloxacin levels in both serum and bronchial secretions. The mean concentrations of pefloxacin in bronchial secretions ranged from 6.51 to 11.1 micrograms/ml and were higher than the corresponding concentrations in serum at all times. Of 61 bronchial specimens, 48 (79%) contained more than 8 micrograms of the antibiotic per ml.

摘要

12例因慢性阻塞性肺疾病急性加重而插管的患者，每隔12小时静脉注射6剂400毫克的培氟沙星。在注射前以及第六次输注结束后的0.5、3、6、9和12小时同时采集血液和支气管分泌物样本。血清和支气管分泌物中的培氟沙星水平存在很大差异。支气管分泌物中培氟沙星的平均浓度范围为6.51至11.1微克/毫升，且在所有时间均高于血清中的相应浓度。在61份支气管标本中，48份（79%）每毫升含有超过8微克的抗生素。