纤维蛋白肽A与甘氨酰-脯氨酰-精氨酰-脯氨酸结合。
Fibrinopeptide A binds Gly-Pro-Arg-Pro.
作者信息
Root-Bernstein R S, Westall F C
出版信息
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4339-42. doi: 10.1073/pnas.81.14.4339.
The tetrapeptide Gly-Pro-Arg-Pro inhibits fibrinogen aggregation, probably by binding to the same sites used during initiation of fibrin formation. The Gly-Pro-Arg-Pro binding sites have not yet been identified. However, their possible sequence and locations have been predicted on the basis of the amino acid pairing hypothesis. One of these predicted sites is on fibrinopeptide A. We report here that nuclear magnetic resonance studies indicate that Gly-Pro-Arg-Pro binds to fibrinopeptide A with a binding constant, K, of ca. 10(4) per mol. We also report results of 19 related peptide combinations used as controls.
四肽甘氨酸 - 脯氨酸 - 精氨酸 - 脯氨酸可能通过与纤维蛋白形成起始过程中使用的相同位点结合来抑制纤维蛋白原聚集。甘氨酸 - 脯氨酸 - 精氨酸 - 脯氨酸的结合位点尚未确定。然而，根据氨基酸配对假说，已经预测了它们可能的序列和位置。其中一个预测位点在纤维蛋白肽A上。我们在此报告，核磁共振研究表明，甘氨酸 - 脯氨酸 - 精氨酸 - 脯氨酸以约每摩尔10⁴的结合常数K与纤维蛋白肽A结合。我们还报告了用作对照的19种相关肽组合的结果。
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