Essatara M B, Levine A S, Morley J E, McClain C J
Physiol Behav. 1984 Mar;32(3):469-74. doi: 10.1016/0031-9384(84)90265-8.
We report the effects of zinc deficiency on normal feeding behavior in rats and the effects of zinc deficiency on stress-induced eating in rats. Zinc deficient (ZD) rats weighed significantly less than their pair-fed and ad lib controls. Zinc repletion allowed improved growth, but ZD rats never displayed catch-up growth compared to their ad lib controls. ZD rats rapidly developed a depressed food efficiency ratio which normalized with zinc supplementation. Food consumption in ZD rats was approximately one-third that of ad lib controls and water intake was also significantly reduced. Mild tail pinch was able to induce feeding in these normally anorexic ZD rats. We conclude that zinc deficiency represents an interesting model of anorexia which may enhance our understanding of appetite regulation.
我们报告了锌缺乏对大鼠正常进食行为的影响以及锌缺乏对大鼠应激诱导进食的影响。缺锌（ZD）大鼠的体重明显低于其配对喂养和自由进食的对照组。补充锌可促进生长，但与自由进食的对照组相比，ZD大鼠从未出现追赶生长的情况。ZD大鼠迅速出现食物效率比降低的情况，补充锌后可恢复正常。ZD大鼠的食物摄入量约为自由进食对照组的三分之一，饮水量也显著减少。轻度夹尾能够诱导这些通常厌食的ZD大鼠进食。我们得出结论，锌缺乏代表了一种有趣的厌食模型，这可能会增进我们对食欲调节的理解。
