Pfenninger E, Ohmann C, Kilian J, Ahnefeld F W
Anaesthesist. 1984 May;33(5):240-3.
Cytostatic treatment with anthracyclines lines can lead to acute or chronic myocardial insufficiency. A cumulative dose of less than 500 mg/m2 body surface area can in general be regarded as safe. A case of acute cardio-circulatory insufficiency during induction of anesthesia is described, in which the total cumulative dose did not exceed 250 mg/m2 body surface area. The pathophysiological mechanisms occurring and the diagnostic and therapeutic measures necessary are discussed.
使用蒽环类药物进行细胞抑制治疗可能导致急性或慢性心肌功能不全。一般认为,体表面积累积剂量低于500mg/m²可视为安全。本文描述了一例麻醉诱导期间发生急性心循环功能不全的病例,其总累积剂量未超过250mg/m²体表面积。文中讨论了所出现的病理生理机制以及必要的诊断和治疗措施。