Grekin R C, Ellis C N
Cutis. 1984 Jul;34(1):90-2.
Two cases of diffuse multiple lesions of sebaceous hyperplasia of the face are reported. The results of both medical and surgical therapies had been unsatisfactory. The patients were treated with low dose systemic isotretinoin (13-cis-retinoic acid) which resulted in complete clearing in one case and substantial clearing in the second. We suggest that in those patients cosmetically bothered by diffuse multiple lesions of sebaceous hyperplasia, for which other therapies are unsuccessful or unamenable to the patient, isotretinoin offers a safe, rational therapeutic option.
报告了两例面部皮脂腺增生弥漫性多发损害的病例。药物治疗和手术治疗的效果均不理想。对患者采用低剂量系统性异维甲酸（13 - 顺式维甲酸）治疗，其中一例完全清除，另一例显著清除。我们建议，对于那些因皮脂腺增生弥漫性多发损害而在美容方面受到困扰、其他治疗方法不成功或患者无法接受的患者，异维甲酸提供了一种安全、合理的治疗选择。
