Lopes C F, Alvarenga R J, Cisalpino E O, Resende M A, Oliveira L G
Int J Dermatol. 1978 Jun;17(5):414-8. doi: 10.1111/ijd.1978.17.5.414.
Twenty-three patients with chromomycosis were treated with oral 5-fluorocytosine for periods ranging from 2 to 67 months. Sixteen were considered cured, after 3 consecutive monthly controls showing healing of the lesions and absence of fungi in mycologic and histopathologic examinations of biopsy specimens. Seven, in spite of initial clinical improvement, showed resistance to treatment. Associated treatment with amphotericin B, calciferol or thiabendazole failed to help patients resistant to 5-fluorocytosine. Resistance seems to occur especially in those with long-standing lesions or widespread involvement.
23例着色芽生菌病患者接受口服5-氟胞嘧啶治疗，疗程为2至67个月。16例在连续3个月每月复查时，活检标本的真菌学和组织病理学检查显示病变愈合且无真菌，被认为已治愈。7例尽管最初临床症状有所改善，但对治疗产生了耐药性。联合使用两性霉素B、骨化醇或噻苯达唑治疗未能帮助对5-氟胞嘧啶耐药的患者。耐药性似乎尤其发生在那些病程较长或病变广泛的患者中。
