Broccia G, Casula P, Andria M
Tumori. 1984 Aug 31;70(4):371-4. doi: 10.1177/030089168407000412.
CML was diagnosed by chance in a 24-year-old woman at the 15th week of pregnancy which, on being informed of her disease she decided to continue. No treatment was given until the 24th week, when WBC reached 140,000/mm3 and it was believed necessary to begin treatment. A program of leukapheresis was started, with the sole aim of reducing the expanding leukemic pool. With 8 leukapheresis, performed at intervals of 2-8 days, WBC were reduced and kept at about 100,000/mm3; after the 8th procedure there was a progressive reduction of WBC to 40,000/mm3, which level was maintained without further treatment for about 4 weeks. Pregnancy and fetal development continued normally. Labor was induced at the 37th week of gestation, and a normal male infant was delivered whose development to date (20 months of age) is normal.
一位24岁的女性在怀孕第15周时偶然被诊断出患有慢性粒细胞白血病（CML），在得知自己的病情后，她决定继续妊娠。直到第24周白细胞计数达到140,000/mm³时才开始治疗，当时认为有必要开始治疗。启动了白细胞单采程序，其唯一目的是减少不断扩大的白血病细胞池。每隔2 - 8天进行一次白细胞单采，共进行了8次，白细胞计数降低并维持在约100,000/mm³；第8次操作后，白细胞计数逐渐降至40,000/mm³，该水平在未进一步治疗的情况下维持了约4周。妊娠和胎儿发育正常进行。在妊娠第37周时引产，分娩出一名正常男婴，其至今（20个月大）发育正常。
