Strobl F J, Voelkerding K V, Smith E P
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
J Clin Apher. 1999;14(1):42-4. doi: 10.1002/(sici)1098-1101(1999)14:1<42::aid-jca8>3.0.co;2-2.
We describe the successful treatment of a pregnant patient with chronic myelogenous leukemia in chronic phase by using only leukapheresis. Following 20 leukapheresis procedures initiated during the 13th week of gestation and performed over approximately 7 weeks, the patients white blood cell count dropped from 242,000/microl to 19,300/microl. The WBC remained stable over the ensuing 17 weeks until the time of delivery. The patient gave birth by cesarean section to a healthy 2,640 g boy at 37.5 weeks of gestation. This is the second report of the successful use of leukapheresis alone for chronic myelogenous leukemia in chronic phase during the first half of pregnancy. We conclude that where leukapheresis is available, it may provide an alternative treatment to chemotherapy or alpha-interferon, especially in light of their potential teratogenic and leukemogenic side-effects.
我们描述了一例仅通过白细胞单采术成功治疗处于慢性期的慢性粒细胞白血病孕妇的病例。在妊娠第13周开始进行了20次白细胞单采术，历时约7周，患者白细胞计数从242,000/微升降至19,300/微升。在随后的17周直至分娩时，白细胞计数保持稳定。患者在妊娠37.5周时通过剖宫产分娩出一名体重2640克的健康男婴。这是第二例关于在妊娠前半期仅使用白细胞单采术成功治疗慢性期慢性粒细胞白血病的报告。我们得出结论，在有白细胞单采术可用的情况下，它可能为化疗或α干扰素提供一种替代治疗方法，特别是考虑到它们潜在的致畸和致白血病副作用。
