Duvivier C, Didelon J, Arnould J P, Zahm J M, Puchelle E, Kopp C, Obrecht B
Biorheology Suppl. 1984;1:119-22. doi: 10.3233/bir-1984-23s121.
In clinical practice, a wide variety of drugs are given to modify the rheological properties of bronchial mucus but they are frequently not correctly chosen because there is not a simple apparatus available for the routine measurement of the mucus viscoelasticity. We designed a new viscoelastometer which is easy to operate and permit accurate measurement of the viscoelastic properties of mucus. The system has a Couette geometry and requires a sample of 1 ml. The outer cylinder is thermostated and rotates at a constant rate. The resulting torque is measured on the inner cylinder using a microdisplacement transducer. The inner cylinder is suspended by a special wire system which maintains a constant 0.75 mm gap between the two cylinders. The apparent viscosity is calculated up to 100 Pa.s. at a low shear rate (0.4 s-1) and the elasticity is analyzed by a stress relaxation method. The characteristics of the apparatus and the typical viscoelasticity behaviour of several sputum samples are reported.
在临床实践中，人们使用各种各样的药物来改变支气管黏液的流变学特性，但由于没有简单的仪器可用于常规测量黏液的黏弹性，这些药物常常未被正确选用。我们设计了一种新型黏弹性测量仪，它操作简便，能够准确测量黏液的黏弹性特性。该系统采用库埃特流变仪结构，所需样品量为1毫升。外筒恒温并以恒定速率旋转。通过微位移传感器在内筒上测量产生的扭矩。内筒由特殊的钢丝系统悬挂，使两筒之间保持恒定的0.75毫米间隙。在低剪切速率（0.4 s⁻¹）下计算表观黏度直至100 Pa·s，并通过应力松弛法分析弹性。本文报道了该仪器的特性以及几个痰液样本的典型黏弹性行为。
