Odom L F, Gordon E M
Blood. 1984 Oct;64(4):875-82.
Four of five infants and young children with acute monoblastic leukemia, a disease that heretofore has been highly refractory to therapy, were successfully treated with sequential infusions of a podophyllin derivative employed as a single agent over a protracted period of time. In three of the five children, monocytic leukemia cutis was present at birth. Treatment was begun in two of them when the disease had progressed to systemic involvement at a few months of age, and in the third when disease was still localized. The other two children were 11 and 18 months of age at initial presentation with widespread disease. Four children are off therapy 11 months, 26 months, 5 years, and 6 years, respectively.
五名患有急性单核细胞白血病的婴幼儿中，有四名此前对治疗高度难治，通过长时间连续输注一种作为单一药物使用的鬼臼脂衍生物而成功得到治疗。在这五个孩子中，有三个在出生时就患有皮肤单核细胞白血病。其中两个孩子在疾病进展到几个月大时出现全身受累时开始治疗，第三个孩子在疾病仍局限时开始治疗。另外两个孩子在初次就诊时分别为11个月和18个月大，病情已广泛扩散。四名儿童分别在停止治疗11个月、26个月、5年和6年后。
