Frankish J D
N Z Med J. 1984 Oct 10;97(765):674-5.
There were 300 admissions to the Cook Hospital with rheumatic fever in 1958-83. During 1958-73 oral penicillin was used for secondary prophylaxis and 77 (35%) of 223 admissions were recurrences. From 1974-83 when parenteral benzathine penicillin was increasingly used there were 77 admissions of which 14 (18%) were readmissions. An effective programme of secondary prophylaxis using benzathine penicillin and co-ordination of hospital and community health services is outlined. One hundred and eight patients with a first attack of rheumatic fever were seen in 1968-82. The chance of a recurrence in patients in whom oral prophylaxis was instituted was 15% two years after the initial attack and 35% after six years. Institution of parenteral prophylaxis significantly reduced the risk of recurrence (p = 0.0009) which was 2% six years after the first attack.
1958年至1983年间，库克医院收治了300例风湿热患者。1958年至1973年期间，口服青霉素用于二级预防，223例入院患者中有77例（35%）复发。1974年至1983年期间，随着长效苄星青霉素的使用越来越多，共有77例入院患者，其中14例（18%）再次入院。本文概述了一项使用长效苄星青霉素进行二级预防的有效方案，以及医院和社区卫生服务的协调情况。1968年至1982年期间，共诊治了108例首次发作风湿热的患者。采用口服预防措施的患者在首次发作后两年复发的几率为15%，六年后为35%。采用注射预防措施可显著降低复发风险（p = 0.0009），首次发作六年后的复发率为2%。
